The primary purpose is to assess the role of sympathetic activation for the development and progression of chronic renal failure. Using microneurography sympathetic activity will be registered in various stages of kidney affection or failure and hypertension. A sympatholytic agent will be compared with a non-sympatholytic drug to asses the effect sympathetic activation and on the progression of kidney disease. The effects of a sympatholytic agent on cardiovascular reactivity to various stressors wil be examined.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
1 mg Rilmenidine per day versus
20 mg Nitrendipine per day
University of Erlangen-Nuremberg, CRC, med. Clinic 4
Erlangen, Bavaria, Germany
sympathetic activation for the development and progression of chronic renal failure
Time frame: 3 months
effects of a sympatholytic agent on cardiovascular reactivity to various stressors
Time frame: 3 months
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