Does Moderate Physical Activity in Hemodialysis Patients Reduce Inflammation?

Martin-Luther-Universität Halle-Wittenberg16 enrolled

Overview

The purpose of this study is to observe a potential benefit of moderate physical activity by using bed mounted cycles during hemodialysis treatment sessions on inflammatory markers in the blood of patients with end-stage renal disease (ESRD).

Patients with ESRD on chronic hemodialysis patients frequently have elevated markers of inflammation (e.g., serum CRP values) and accumulation of proinflammatory monocyte populations in the circulation. The level of inflammation is highly predictive for cardiovascular disease and mortality. Physical activity has been shown to improve dialysis efficacy by improving the elimination of retention solutes. In healthy individuals, sports activity influences inflammatory immune parameters. The study will observe the influence of moderate physical activity (using a bed mounted cycle for 30min during dialysis thrice weekly) on circulating monocyte subpopulations and inflammatory proteins over a 9 month period in 16 chronic hemodialysis patients.

Study Type

OBSERVATIONAL

Enrollment

Conditions

End-stage Renal Disease Hemodialysis

Interventions

moderate physical activityBEHAVIORAL

bed mounted cycles for physical activity for 30 min during each hemodialysis session

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * chronic hemodialysis treatment for at least three months * three dialysis sessions per week * good general clinical condition * stable hemodynamics during the most recent three dialysis sessions Exclusion Criteria: * conditions making the patient unable to use the bed mounted cycle (amputations, joint disease etc) * clinically obvious acute infections * active malignancy * pathologic results of spiroergometry or echocardiography that imply an elevated risk of participation * myocardial infarction within the last 12 weeks * uncontrolled arterial hypertension * uncontrolled diabetes mellitis with frequent hypoglycemia * unability to understand and consent the protocol

Locations (1)

Department of Internal Medicine II

Halle, Saxony-Anhalt, Germany

Outcomes

Primary Outcomes

Composition of monocyte subpopulations as defined by CD14 and CD16 expression

Time frame: 6 months

Secondary Outcomes

Serum CRP values

Time frame: 6 months

Dialysis quality (kt/V, URR)

Time frame: 6 months

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.