The Effect of Marijuana and Prescription Medications in Mood, Performance and Sleep

Johns Hopkins University36 enrolled

Overview

Heavy marijuana users report experiencing trouble sleeping when they try to quit, but this has not been carefully studied. This research is being done to learn more about sleep function in heavy marijuana users, and to determine whether a medication approved for treating insomnia can help restore normal sleep function during brief periods of abstinence.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Marijuana Dependence

Interventions

eszopicloneDRUG

Oral capsule at dose recommended for adults

PlaceboDRUG

Participants receive placebo prior to sleep

ramelteonDRUG

ramelteon

zolpidem

Eligibility

Sex: ALLMin age: 18 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * current use of marijuana * able to give informed consent Exclusion Criteria: * dependence on drug other than marijuana * current sleep disorder * pregnant, breast feeding, or planning to become pregnant within the next 3 months * currently seeking treatment for cannabis-related problems or otherwise trying to reduce use * use of cannabis under the guidance of a physician for a medical disorder * unstable or uncontrolled cardiovascular disease (e.g., hypertension, angina) * allergy to study medication

Locations (1)

Johns Hopkins University

Baltimore, Maryland, United States

Outcomes

Primary Outcomes

Marijuana Withdrawal

Time frame: Every day during study participation

Secondary Outcomes

Objective Sleep Assessment

Time frame: Every day during study participation

Cognitive Performance

Time frame: Every day during study participation

Data from ClinicalTrials.gov

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