Critical Illness Neuromuscular Abnormalities in Neurocritical Care Patients

Clinical Institute of the Brain, Russia135 enrolled

Overview

The aim of this research is to investigate critical illness neuromuscular abnormalities in neurocritical care patients.

Since 1984, the problem of critical illness neuromuscular abnormalities (CINMAs) has attracted considerable interest. According to these studies, CINMAs include the muscular weakness that accompanies critical illness resulting from polyneuropathy and/or myopathy and can be seen in 25-85% of cases of critically ill patients. Clinically, CINMAs present as symmetric flaccid tetraparesis and difficulty weaning off mechanical lung ventilation. However, these data are derived from treating non-specialized intensive care unit (ICU) patients. In this research, we wished to investigate CINMAs in neurocritical care patients. From day one of the patients' participation in the research and until a discharge from the ICU (or death), daily neurological surveys and weekly nerve conduction studies were performed. Based on the results of each nerve conduction study, an index of neuromuscular damage was noted to evaluate the severity of the CINMAs. Needle electromyography and muscle biopsy were not used

Study Type

OBSERVATIONAL

Enrollment

135

Conditions

Muscle Weakness Critical Illness

Eligibility

Sex: ALLMin age: 16 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age: 16 years and older * Acute primary cerebral pathology * Mechanical ventilation * Signs of systemic inflammatory response * Exclusion of the possibility of an initial pathology of the spinal cord, peripheral nervous system and muscles in past medical history Exclusion Criteria: * Brain stem or bilateral hemispheric lesions with tetraparesis at the onset of illness * Inability to perform high-grade nerve conduction studies

Locations (1)

Clinical Institute of the Brain

Yekaterinburg, Russia

Outcomes

Primary Outcomes

incidence of critical illness neuromuscular abnormalities (CINMAs)

Time frame: within the first week of mechanical ventilation

Secondary Outcomes

clinical and neurophysiological characteristics of CINMAs

Time frame: within the first week of mechanical ventilation

influence оf phrenic nerve pathology on weaning from mechanical ventilation

Time frame: during weaning period

dynamics of the neurophysiological characteristics of CINMAs

Time frame: during stay in ICU

Data from ClinicalTrials.gov

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