Bipolar Study of Seroquel XR With Pramipexole Dihydrochloride

Inclusion Criteria: * You must be between 18 years and 65 years of age. * You must have been diagnosed with bipolar depression. * You must (for women who are able to become pregnant) have a negative urine human chorionic gonadotropin (HCG) pregnancy test at enrolment and be using a reliable form of birth control for the entire duration of the study. The study staff will inform about what is considered an acceptable method of birth control. * You must provide consent. * You must be able to understand and comply with the requirements of the study Exclusion Criteria: * You are pregnant or lactating (breast-feeding), * Your symptoms are due to the direct physiological effects of a substance (e.g. drug of abuse, medication, or other treatment) or a general medical condition, * You have a primary psychotic disorder (e.g., schizophrenia), * You have a personality disorder diagnosis which in the study doctor's opinion is the focus of clinical concern. * You have a history or presence of any psychotic illness, including major depression with psychotic features. * In the opinion of the study doctor, you pose an imminent risk of suicide or a danger to yourself or others, * You have known allergies to quetiapine or to components of the medication capsule, * You use any "prohibited" medications. You must inform the study coordinator or study doctor of all the medications that you are taking, and he/she will tell you if any of those medications exclude you from the study. * You have a substance dependence (drug or alcohol dependence) which in the study doctor's opinion is the focus of clinical concern, * You have a medical condition that would affect absorption, distribution, metabolism, or excretion of the medication, * You have an unstable or inadequately treated medical illness (e.g. unstable diabetes, angina pectoris, hypertension) as judged by the study doctor, * You have diabetes mellitus (DM) which, in the opinion of the study doctor, would exclude you from the study, * You have an absolute neutrophil count (ANC) of ≤1.5 x 109 per liter * You are involved in the planning and conduct of the study , * You were previously enrolled or randomized in this present study, * You participated in another drug trial within 4 weeks prior enrolment into this study