Norepinephrine as Early Vasopressor Therapy in Children Undergoing Mechanical Ventilation

Unidade de Terapia Intensiva40 enrolled

Overview

The purpose of this study is to assess the effectiveness from early infusion of norepinephrine in pediatric patients submitted to mechanical ventilation for the use of sedative and analgesics drugs.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Shock Mechanical Ventilation

Interventions

NorepinephrineDRUG

Solution administration contend titrated norepinephrine in doses of 0,1 to 0,4 mc/kg/min. Initiated solution 24 hours after beginning mechanical ventilation. Use of the solution during 72 hours.

PlaceboDRUG

Eligibility

Sex: ALLMin age: 1 MonthMax age: 12 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Children, who, in the arrival or during the admission in pediatric intensive care unit, develop the need for mechanical ventilation and continuous infusion of sedatives and/or analgesics Exclusion Criteria: * Patients after cardiac arrest * Patients with tracheostomy * Patients with renal and/or hepatic failure * Patients with previous episode of cardiac arrythmia * Patients with mechanical ventilation forecast lesser that four days

Locations (1)

Hospital Geral

Caxias do Sul, Rio Grande do Sul, Brazil

Outcomes

Primary Outcomes

To compare norepinephrine and placebo as initial therapy in pediatric patients submitted to the mechanical ventilation with reference to hemodynamic parameters, diuresis and diuretics' use.

Time frame: 5 days

Secondary Outcomes

To assess possible side effects related with the early norepinephrine infusion.

Time frame: 5 days

Data from ClinicalTrials.gov

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