Alternative Options to Minimize Niacin-Induced Flushing

Inclusion Criteria: * An adult between 21 and 70 years of age. * Male or female (If female must be postmenopausal for at least 1 year, surgically sterile or using an effective form of contraception). * Able to speak and read English. * Willing to comply with study specific instructions, and complete all study procedures according to protocol. * Able to understand study rationale and sign informed consent. Exclusion Criteria: * Females of child-bearing potential not using acceptable method of contraception and perimenopausal females. * History of gout * History of diabetes mellitus * History of coronary heart disease * History of, or currently experiencing, renal disease including, but not limited to, renal insufficiency, nephrolithiasis or chronic renal failure. * History of, or currently experiencing, major chronic gastrointestinal condition including gallbladder disease, liver disease and peptic ulcer disease * Known sensitivity to niacin, Aspirin or nonsteroidal anti-inflammatory agents (NSAIDs) * History of migraine or cluster headaches * Currently using antihistamines, aspirin or NSAIDS on a consistent basis * Presence or history of any medical or psychosocial condition that, in the opinion of the investigator, would limit the patient's successful participation or would compromise the patient's safe participation. * Lab abnormalities at screening, including but not limited to elevated liver enzymes or blood sugar levels that might indicate additional risk to the patient's continued participation. * Currently taking medication that might be contraindicated with the study drug or Niacin or study procedures (including Niacin, lipid-lowering drugs, chronic aspirin or laxative use). * Clinically significant finding from physical exam that would affect the patient's safe participation or completion of the study.