RATIONALE: Collecting samples of tumor tissue from patients with cancer to study in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer. PURPOSE: This laboratory study is looking at HER-2 mutations in tumor samples from patients with advanced non-small cell lung cancer being treated with trastuzumab on clinical trial ECOG-2598.
OBJECTIVES: * Correlate clinical response to trastuzumab (Herceptin®) with the presence of mutation in the HER-2 kinase domain in tumor samples from patients with advanced non-small cell lung cancer treated on protocol ECOG-2598. * Correlate mutations with time to progression and survival of these patients. OUTLINE: This is a multicenter study. Tissue specimens are analyzed by polymerase chain reaction to assess mutations in the HER-2 gene. Laboratory/biomarker analysis data is correlated with clinical data from protocol ECOG-2598. PROJECTED ACCRUAL: A total of 22-44 patients will be accrued for this study.
Study Type
OBSERVATIONAL
Enrollment
44
Correlation of HER-2 mutation with response, time to progression, and survival
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