Umbilical Cord Blood Transplantation As Treatment Of Adult Patients With Hematologic Disorders

Inclusion Criteria: Patients must have a histologically confirmed diagnosis at The Vancouver General Hospital or the BCCA-Vancouver. Eligible patients will have one of the following underlying diseases: * High risk acute lymphoblastic leukemia (ALL) in first complete remission, with high risk being defined by the presence of t(4;11), t(9;22) or t(1;19) or patients presenting with extreme hyperleukocytosis (WBC \>100x109/L) or failure to achieve a complete remission after standard induction therapy. * Acute myeloid leukemia (AML) in first complete remission with high risk cytogenetics or failure to achieve complete remission after standard induction therapy. ALL or AML in second or subsequent remission * Myelofibrosis with myeloid metaplasia. * Chronic myeloid leukemia in chronic (failed interferon and/or Gleevec) or accelerated phase. * Myelodysplastic syndrome with IPSS risk category \>Int-1 * Aplastic anemia * Non-Hodgkin's lymphoma, chronic lymphocytic leukemia or Hodgkin's disease in relapse or second or subsequent remission. * Multiple Myeloma * No active central nervous system (CNS) disease. * No 9/10 or better HLA antigen matched related donor or VUD available. * The patient's condition precludes waiting to search and find a VUD in the Unrelated Donor Registries * Acceptance of standard blood product support * Adequate organ function as defined by current Leukemia/BMT Program of BC standards (Appendix 10.1) * Karnofsky performance status ≥ 80 (Appendix 10.2) Exclusion Criteria: * Active infection * Pregnancy * Significant psychiatric disorder * Progressive disease