RATIONALE: Changing the genes in laboratory mice to create a living model of human breast cancer may help doctors learn more about breast cancer. PURPOSE: This research study is developing mouse models of breast cancer using tissue samples that were previously collected from women with breast cancer.
OBJECTIVES: * To develop new in vivo models of human breast cancer. * To correlate response in this model to actual treatment outcome in patients, if the in vivo model is proven feasible. OUTLINE: Previously collected breast tumor fragments are implanted into the renal capsule site of SCID mouse hosts (mouse with severe combined immune deficiency) to establish metastatic spread patterns, and both histologic and molecular tumor characteristics. Patients' medical charts are reviewed to obtain relevant information, including general demographics, smoking and alcohol use, as well as outcome data such as survival and response to treatment.
Study Type
OBSERVATIONAL
Enrollment
26
Tissue samples will either be collected at the time of medically indicated surgical procedures or through research core biopsies. A sample of urine will also be obtained. Blood will be collected via venipuncture and lymphocytes (mononuclear cells) separated and processed as a source of normal DNA and normal cells.
patient chart review will occur in conjunction with patient data collection for final analyses.
Vanderbilt-Ingram Cancer Center
Nashville, Tennessee, United States
Development of new in vivo models of human breast cancer
Time frame: 1 year
Correlation of response in this model to actual treatment outcome in patients, if the in vivo model proven feasible
Time frame: 5 years
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