Bone Marrow and Blood Samples From Patients With Metastatic Choroid Melanoma

Institut Curie15 enrolled

Overview

RATIONALE: Studying samples of bone marrow and blood from patients with cancer may help doctors find out the extent of disease. PURPOSE: This research study is collecting bone marrow and blood samples from patients with metastatic choroid melanoma.

OBJECTIVES: Primary * Develop and validate a method of detecting tumor cells in the bone marrow and blood in patients with metastatic choroid melanoma. OUTLINE: While patients are under general anesthesia for standard treatment of their disease, samples of bone marrow from the iliac crest and blood are collected. Samples are analyzed for the expression of tyrosinase and Melan-a via RT-PCR.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Intraocular Melanoma

Interventions

gene expression analysisGENETIC

reverse transcriptase-polymerase chain reactionGENETIC

laboratory biomarker analysisOTHER

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

DISEASE CHARACTERISTICS: * Choroid melanoma * Metastatic disease * Planning to undergo general anesthesia PATIENT CHARACTERISTICS: * Not pregnant or nursing * No contraindications to the collection of a bone marrow sample * No patient deprived of liberty or under trusteeship (including guardianship) * No social or psychological situations that preclude the ability to give consent PRIOR CONCURRENT THERAPY: * Not specified

Outcomes

Primary Outcomes

Detection of micro-metastatic cells in 20 x 10^6 nucleated cells

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.