Gene Expression Profiles in Patients With Metastatic Pancreatic Cancer

Barbara Ann Karmanos Cancer Institute10 enrolled

Overview

RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer. PURPOSE: This laboratory study uses gene expression profiling to compare primary tumor cells with metastatic tumor cells in patients with metastatic pancreatic cancer.

OBJECTIVES: * Compare the gene expression profiles of pancreatic cancer cells from the primary and metastatic sites in patients with metastatic pancreatic cancer. * Characterize the function of the differentially upregulated and downregulated genes identified by comparing the gene expression profiles of primary and metastatic cells in these patients. OUTLINE: Fresh biopsy samples are collected for gene expression profiling and other biomarker/laboratory analyses. PROJECTED ACCRUAL: A total of 10 patients will be accrued for this study.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Pancreatic Cancer

Interventions

microarray analysisGENETIC

laboratory biomarker analysisOTHER

Eligibility

Sex: ALL

Medical Language ↔ Plain English

DISEASE CHARACTERISTICS: * Diagnosis of pancreatic adenocarcinoma of exocrine origin * Metastatic disease * Fresh biopsy material available from primary site of disease and a metastatic focus, including liver, peritoneum, or lymph node PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * No prior chemotherapy or radiotherapy for pancreatic cancer

Locations (1)

Barbara Ann Karmanos Cancer Institute

Detroit, Michigan, United States

Outcomes

Primary Outcomes

Gene expression profiles

Time frame: at time of biopsy

Data from ClinicalTrials.gov

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