Study of DNA Samples From Patients With Multiple Myeloma

Overview

RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer. PURPOSE: This laboratory study is looking at DNA samples from patients with multiple myeloma.

OBJECTIVES: * Determine whether there is an increased frequency of 1 or more polymorphic alleles that are associated with clinical endpoints using custom myeloma single nucleotide polymorphism (SNP) chip analysis of banked DNA samples from patients with multiple myeloma. * Determine SNPs associated with toxicities caused, not by variations in tumor cell genetics, but by individual genetic variations affecting drug activation, distribution, metabolism, and export (ADME). * Determine SNPs associated with response, influenced by the same ADME. * Determine SNPs associated with bone disease (as a variable) among patients with multiple myeloma. * Determine SNPs associated with epidemiology (i.e., risk factors for the development of multiple myeloma). OUTLINE: This is a retrospective, multicenter study. Banked DNA samples are analyzed using a custom single nucleotide polymorphism (SNP) chip to assess approximately 3,590 SNPs from 1,061 genes that are associated with myeloma growth and response. PROJECTED ACCRUAL: A total of 600 patients will be accrued for this study.

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