Effect of Daily Low Dose Aspirin on Exhaled Inflammatory Mediators in Normal Subjects

Brigham and Women's Hospital4 enrolled

Overview

Hypothesis: Low dose aspirin does not change exhaled inflammatory breath mediators in normal subjects.

Aim: 1. To study the effect of low dose aspirin on exhaled breath inflammatory mediators 2. To compare the change to that seen in diseased states such as asthma and Lymphangioleiomyomatosis (LAM) We will interview healthy volunteers to confirm that they do not have any major underlying medical conditions such as heart disease, diabetes, stroke and bleeding disorders. We will collect breath condensate before and after two weeks of low dose over the counter enteric coated aspirin 81 mg/day therapy. Side effects are extremely rare at this dose, but include bleeding, heart burn and allergic reaction.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Healthy

Interventions

aspirinDRUG

81 mg orally daily for two weeks

Eligibility

Sex: ALLMin age: 18 YearsMax age: 95 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * healthy adults Exclusion Criteria: * any underlying major medical conditions such as heart disease, hypertension, stroke, diabetes, bleeding disorders

Locations (1)

Asthma Research Center, Brigham and Women's Hospital

Boston, Massachusetts, United States

Outcomes

Primary Outcomes

Change in Exhaled Inflammatory Mediator Levels

Descriptive statistics

Time frame: baseline and 6 months

Data from ClinicalTrials.gov

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