Safety and Efficacy Study of P276-00 in Combination With Gemcitabine in Patients With Advanced Pancreatic Cancer

Inclusion Criteria: 1. Histologically or cytologically confirmed diagnosis of infiltrating ductal adenocarcinoma of pancreas. 2. Chemonaive patients i.e. patients must not have received chemotherapy or biologic/targeted anticancer therapy for the adenocarcinoma of pancreas. 3. Locally advanced inoperable pancreatic cancer. 4. Patients of either sex, aged \> or = 18 years. 5. Karnofsky performance status of \> or = 60%. 6. Adequate bone marrow reserve: white blood cell (WBC) count \> or = 4 x 109/l, Absolute neutrophil count (ANC) ≥ 1.5 x 109/l, platelets \> or = 100 x 109/l, hemoglobin \> or = 10 g/dl. 7. Adequate liver function: bilirubin \< or = 1.5 times the upper normal value, ALT/AST/ alkaline phosphatase less than 3 times the upper normal value (unless due to liver metastases in which case bilirubin less than 3 times the upper normal value, ALT/AST less than 4 times the upper normal value, and alkaline phosphatase without limit). 8. Adequate renal function: creatinine ≤ 1.5 times the upper normal value. 9. If female: * Childbearing potential either terminated by surgery, radiation, or menopause, or attenuated by use of at least 2 approved contraceptive methods (at least one should be a barrier method) during and for 4 weeks after stopping the study treatment. * Negative urine β-HCG test within 1 week prior to protocol entry where childbearing potential is not terminated. 10. Additional inclusion criterion only for part B: Patient should satisfy at least one of the following criteria on cycle 1 day 1: * Karnofsky performance status of 60 or 70 * Baseline pain intensity score of \> or = 20 mm Exclusion Criteria: 1. Inability / unwillingness to give consent. 2. Pregnant or breast feeding women. 3. Brain metastasis (active or inactive). 4. Serious concomitant systemic disorders incompatible with the study (at the discretion of the investigator). 5. Patients known to be suffering from infection with HIV, Hepatitis C or Hepatitis B. 6. Patients who had received any other investigational drug within 1 month prior to Day 1 of protocol treatment. 7. Patients with QTc \> 450 msec on 12-lead standard electrocardiogram (ECG). 8. Major surgery within 2 weeks prior to protocol treatment. 9. Radiotherapy to \> 10% of bone marrow. 10. Patients with 3rd space fluid accumulation (ascites, pleural effusion).