Matrix Metalloproteinases After Surgery and/or Radiofrequency Ablation in Patients With Liver Metastases From Colorectal Cancer

University Hospital, Grenoble75 enrolled

Overview

RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors predict how patients will respond to treatment. PURPOSE: This research trial is studying matrix metalloproteinases after surgery or radiofrequency ablation in patients with liver metastases from colorectal cancer.

OBJECTIVES: Primary * Describe the kinetics of postoperative changes of serum matrix metalloproteinases (MMP) (MMP-1, MMP-2, MMP-7, MMP-9) and their inhibitors (TIMP) (TIMP-1, TIMP-2) as a function of surgical technique. Secondary * Determine the predictive value of postoperative risk of recurrence. * Correlate the risk of recurrence with surgical technique. * Determine whether elevated serum levels of MMP are a better marker than the carcinoembryonic antigen of hepatic or extrahepatic recurrence. * Determine whether the postoperative serum of HGF/SF is correlated to changes in plasma levels of MMPs. OUTLINE: Blood samples are collected periodically before and after treatment to analyze for metalloproteinases and their inhibitors. After completion of study treatment, patients are followed at day 45 and then every 3 months for 2 years.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Colorectal Cancer Metastatic Cancer

Interventions

laboratory biomarker analysisOTHER

cryosurgeryPROCEDURE

radiofrequency ablationPROCEDURE

therapeutic conventional surgeryPROCEDURE

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

DISEASE CHARACTERISTICS: * Meets 1 of the following criteria: * Patients with histologically confirmed adenocarcinoma of the colon or rectum and liver metastases * Must have undergone prior complete resection of the tumor more than 3 months ago * Liver metastases must be resectable or accessible for radiofrequency ablation * Patients undergoing cryosurgery of the digestive tract for a reason other than cancer or infection (control) PATIENT CHARACTERISTICS: * No other neoplastic disease that is measurable or being treated other than colorectal cancer * No heart failure or severe respiratory disease * No uncontrolled infection or other severe disease PRIOR CONCURRENT THERAPY: * See Disease Characteristics * No participation in another study involving new drugs

Outcomes

Primary Outcomes

Kinetics of postoperative changes of serum matrix metalloproteinases (MMP) and their inhibitors (TIMP)

Secondary Outcomes

Predictive value of postoperative risk of recurrence

Correlation of risk of recurrence with surgical technique

Elevated serum levels of MMP vs carcinoembryonic antigen as a marker of hepatic or extrahepatic recurrence

Correlation of postoperative serum HGF/SF with plasma levels in MMPs

Data from ClinicalTrials.gov

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