RATIONALE: Studying the proteins expressed in samples of tumor tissue from patients with cancer may help doctors identify and learn more about biomarkers related to cancer. It may also help doctors plan better treatment for patients with cancer of the oropharynx. PURPOSE: This laboratory study is looking at protein expression in tumor tissue samples from patients with cancer of the oropharynx.
OBJECTIVES: * To investigate if some of the differences in gene expression are also reflected at the protein level. * To determine whether differences in gene expression that are also reflected at the protein level can be used to develop markers for early detection and disease surveillance. * To identify targets for therapy. OUTLINE: Archived tumor tissue samples are analyzed for expression of standard immunohistological markers (e.g., p16, p53, and Ki-67) as well as expression of genes identified in a previous gene expression study. Protein expression data are tested for clinical and demographic correlates and compared with gene expression data.
Study Type
OBSERVATIONAL
Enrollment
54
profiles of HPV(+) and (-) HNSCCs
microarray analysis
protein expression analysis
Development of biomarkers for early detection or recurrence surveillance
Time frame: after 7 months of tissue collection
Identification of therapeutic targets and individualization of treatment based on the biology of squamous cell carcinoma of the oropharynx
Time frame: after 7months of tissue collection
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immunohistochemistry staining method
laboratory biomarker analysis