Molecular Markers in Predicting Lung Cancer Development Using Tissue Samples From Healthy Participants

Vanderbilt-Ingram Cancer Center37 enrolled

Overview

RATIONALE: Studying samples of blood, urine, sputum, mouth cells, and bronchial tissue from healthy participants in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors learn more about the development of cancer. PURPOSE: This laboratory study is looking for molecular markers in predicting lung cancer development using tissue samples from healthy participants.

OBJECTIVES: * To obtain biological specimens from healthy participants with no known risk of lung cancer to use as controls in the study of lung cancer progression. * To identify new molecular abnormalities specific to the development of squamous cell carcinoma of the lung. OUTLINE: Serum, urine, sputum, and buccal cell samples are collected. Patients also undergo bronchoscopy for collection of bronchial tissue and bronchial brush samples. The samples are used for genomic and proteomic studies to identify new molecular abnormalities specific to the development of lung cancer.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Healthy, no Evidence of Disease Lung Cancer

Interventions

proteomic profilingGENETIC

Collection of tissue, blood, urine, mouth cells, spit, nasal airway cells and breath

biologic sample preservation procedureOTHER

Collection of tissue, blood, urine, mouth cells, spit, nasal airway cells and breath

laboratory biomarker analysisOTHER

Collection of tissue, blood, urine, mouth cells, spit, nasal airway cells and breath

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

DISEASE CHARACTERISTICS: * Healthy participant * No history of smoking * No history of cancer PATIENT CHARACTERISTICS: * SWOG performance status 0 * No clinically apparent bleeding diathesis PRIOR CONCURRENT THERAPY: * Not specified

Locations (3)

Vanderbilt-Ingram Cancer Center - Cool Springs

Nashville, Tennessee, United States

Vanderbilt-Ingram Cancer Center at Franklin

Nashville, Tennessee, United States

Vanderbilt-Ingram Cancer Center

Nashville, Tennessee, United States

Outcomes

Primary Outcomes

Collection of biological specimens to use as controls in the study of lung cancer progression

Specimens are collected from healthy participants with no known risk of lung cancer

Time frame: Off study date, up to one year

Secondary Outcomes

Identification of new molecular abnormalities specific to the development of squamous cell carcinoma of the lung

Time frame: off-study date, up to one year

Selection of important genes/proteins differentially expressed between study groups (e.g., normal vs low-grade vs high-grade vs invasive) and between normal smokers vs normal non-smokers

Time frame: off-study date, up to one year

Data from ClinicalTrials.gov

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