RATIONALE: Collecting and storing samples of tumor tissue from patients with Fanconi anemia to test in the laboratory may help the study of cancer in the future. PURPOSE: This laboratory study is collecting and storing tumor tissue samples from patients with Fanconi anemia.
OBJECTIVES: * Acquire rare solid tumor samples from patients with Fanconi anemia in order to create a Fanconi Anemia Cell Repository at the Oregon Health and Science University Cancer Institute. * Study repository tissue using a variety of molecular methods, including gene microarrays. * Develop cancer cell lines that are publicly available from tissue archived from patients with Fanconi anemia. OUTLINE: Tumor biopsies are collected from patients with Fanconi anemia and archived for future molecular studies, cell line generation, and general usage by the research community at large. Medical information about the patient's cancer is also archived. PROJECTED ACCRUAL: Not specified.
Study Type
OBSERVATIONAL
Enrollment
8
Once the pathologist has taken the material needed to establish diagnosis of cancer, the anonymized snap-frozen and fresh samples will be either shipped to our laboratory for analysis or will be picked up by a member of the principal investigator's lab team. Samples will be stored indefinitely.
Once the pathologist has taken the material needed to establish diagnosis of cancer, 1-10 grams of the remaining tissue should be placed in phosphate buffered saline and shipped to the Bagby Lab.
Knight Cancer Institute at Oregon Health and Science University
Portland, Oregon, United States
Creation of a Fanconi Anemia Cell Repository using rare solid tumor samples from patients with Fanconi anemia
Time frame: Duration of the study
Study tissue samples by molecular methods, including gene microarrays
Time frame: Duration of the study
Development of cancer cell lines from tissue archived from patients with Fanconi anemia
Time frame: Duration of the study
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