RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research study is looking at tissue samples in predicting oral cancer in patients who have undergone neck dissection for oral cancer.
OBJECTIVES: * To test preliminary data from node-positive oral squamous cell carcinoma (OSCC) signatures for their ability to predict lymph-positive primaries using a cohort of OSCC tumors. * To perform lymph node prediction using sentinel lymph node-biopsied primaries. * To validate the preliminary data node-positive OSCC signature and test its ability to predict nodal status. OUTLINE: Patient tissue samples are screened using polymerase chain reaction (PCR) for human papilloma virus-specific primers. Samples are analyzed to identify a nodal-metastasis signature for oral squamous cell carcinoma. Samples also undergo microarray analysis to quantify expression levels for targeted genes. Initial data analysis is performed using Affymetrix® Microarray Suite 5.0 to quantify expression levels for targeted genes.
Study Type
OBSERVATIONAL
Abramson Cancer Center of the University of Pennsylvania
Philadelphia, Pennsylvania, United States
overall survival
Time frame: Up to 5 years
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