RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research study is looking at molecular markers and genetic markers in patients undergoing radiation therapy for cancer.
OBJECTIVES: Primary * Determine local-regional control in patients undergoing radiation therapy for cancer, as a function of expression of specific molecular/genetic markers. Secondary * Determine complications of radiation therapy for patients undergoing radiation therapy for cancer. OUTLINE: Previously collected tissue samples are analyzed using immunohistochemical staining and other molecular/genetic study methods to detect markers, including p53, cyclin D1, HER-2-neu, bcl-2/BAX, and EGFR. Patient charts are also reviewed with emphasis on local-regional relapse.
Study Type
OBSERVATIONAL
Rutgers Cancer Institute of New Jersey - Robert Wood Johnson Medical School
New Brunswick, New Jersey, United States
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