RATIONALE: Studying samples of blood in the laboratory from patients with cancer may help doctors learn more about nausea and vomiting caused by cancer treatment. PURPOSE: This laboratory study is looking at blood samples from patients with cancer who were treated on a clinical trial to control nausea and vomiting during donor stem cell transplant.
OBJECTIVES: Primary * To compare the amount of substance P in serum samples from patients with cancer treated with busulfan/cyclophosphamide or cyclophosphamide/total body irradiation conditioning regimens prior to undergoing allogeneic hematopoietic stem cell transplantation. Secondary * To assess the changes in substance P over time to see if there is an optimal time shown by this physiologic correlate to discontinue substance P blockade after the chemotherapy regimen is completed in these patients. OUTLINE: Previously collected serum samples are analyzed by enzyme immunoassay for changes in substance P levels. Patients' medical records are reviewed for demographic information, past history, and course of treatment.
Study Type
OBSERVATIONAL
Enrollment
9
OHSU Knight Cancer Institute
Portland, Oregon, United States
Average, median, and mode for substance P levels at different times
Correlation of substance P levels with patient response (emesis or not)
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.