RATIONALE: Collecting and storing samples of tumor tissue from patients with soft tissue sarcoma to test in the laboratory may help the study of cancer in the future. PURPOSE: This laboratory is collecting tissue samples from patients with soft tissue sarcoma of the arms, hands, legs, or feet treated on clinical trial CRUK-VORTEX.
OBJECTIVES: * Determine early in the course of treatment which patients treated on clinical trial CRUK-VORTEX have an increased likelihood of distant metastases so as to highlight individuals who might benefit from early adjuvant systemic therapy. OUTLINE: This is a multicenter study. Tumour and normal tissue samples will be taken at the time of surgery during treatment on clinical trial CRUK-VORTEXand preserved for future microarray analyses. Tissue microarrays will be produced from both tumor and normal tissues. Blood samples will be collected for future DNA analysis.
Study Type
OBSERVATIONAL
Enrollment
400
Queen Elizabeth Hospital at University Hospital of Birmingham NHS Trust
Birmingham, England, United Kingdom
RECRUITINGRoyal Orthopedic Hospital NHS Trust
Birmingham, England, United Kingdom
Increased likelihood of distant metastases
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Bristol Haematology and Oncology Centre
Bristol, England, United Kingdom
RECRUITINGGloucestershire Oncology Centre at Cheltenham General Hospital
Cheltenham, England, United Kingdom
RECRUITINGRoyal National Orthopaedic Hospital NHS Trust
Cheltenham, England, United Kingdom
RECRUITINGMiddlesex Hospital
London, England, United Kingdom
RECRUITINGChristie Hospital
Manchester, England, United Kingdom
RECRUITINGNottingham City Hospital
Nottingham, England, United Kingdom
RECRUITINGCancer Research Centre at Weston Park Hospital
Sheffield, England, United Kingdom
RECRUITINGRobert Jones and Agnes Hunt Orthopaedic and District Hospital NHS Trust
Shropshire, England, United Kingdom
RECRUITING...and 2 more locations