RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research study is looking at tumor tissue samples from patients with soft tissue sarcoma.
OBJECTIVES: * To develop a pilot program for the collection, archiving, and experimental analyses of soft tissue sarcomas (STS). * To obtain STS tumors from cancer patients undergoing tumor removal or core needle biopsies. * To evaluate cellular and molecular factors involved in STS oncogenesis by studying samples derived from human tumor specimens. * To develop an accompanying bioinformatics database of the demographics of STS patients from which tumor specimens are derived for experimental study. OUTLINE: Tumor tissue samples are analyzed for gene and protein expression by cDNA microarray analysis, RT-PCR, immunohistochemistry, in vitro transformation assays, RNA interference, and Western blot or immunoprecipitation.
Study Type
OBSERVATIONAL
Enrollment
27
Arizona Cancer Center at University of Arizona Health Sciences Center
Tucson, Arizona, United States
Identification of molecular targets that would improve the diagnosis, prognosis, and/or treatment of STS
Time frame: 3 months
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