RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about nutrition-related changes that identify biomarkers related to cancer. It may also help doctors predict a woman's risk of developing breast cancer. PURPOSE: This laboratory study is looking at nutrition-related biomarkers in predicting breast cancer risk in women.
OBJECTIVES: * To complete characterization of metabolic serotypes based on the metabolome, and to adapt these profiles for human epidemiological studies. * To determine the extent to which metabolic profiles that are reflective of or independent of long-term caloric intake predict breast cancer risk in nested case-control studies. * To identify critical serum metabolites. OUTLINE: Laboratory studies, including metabolome profiling by high performance liquid chromatography; and small molecule identification by mass spectroscopy, are performed on previously collected blood samples.
Study Type
OBSERVATIONAL
Enrollment
1,500
Dana-Farber/Brigham and Women's Cancer Center
Boston, Massachusetts, United States
Generation of metabolome profiles that reflect nutritional status
Time frame: ongoing
Utility of rat metabolome profiles for human epidemiological studies
Time frame: ongoing
Utility of metabolome profiles in predicting relative risk of developing breast cancer
Time frame: ongoing
Identification of critical serum metabolites
Time frame: ongoing
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