Effect of Systemic Ropivacaine on Hyperalgesia, Flare Reaction and Peripheral Nerve Excitability

University of Zurich34 enrolled

Overview

The purpose of this study is to compare the effect of intravenous ropivacaine and lidocaine on the receptive field of primary sensory afferents and their influence on the vascular bed. \*Trial with medicinal product

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Healthy Volunteers

Interventions

ropivacaine (Naropin)DRUG

intravenous infusion 1 mg/kg bw

Eligibility

Sex: MALEMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion criteria: 1. Male 2. Age: 18 - 65 years 3. Weight: 50-100kg 4. Height: 155-195cm 5. Signed and dated informed consent 6. Sufficient command of German language Exclusion criteria: 1. Contraindications to the class of drugs under study 2. Vulnerable subjects (intellectually or mental impaired) 3. Known hypersensitivity to class of drugs or the investigational product 4. Drug abuse 5. Known peripheral neuropathies 6. Diabetes mellitus 7. Chronic alcohol consumption 8. Congestive heart disease 9. Participants of other studies during study period 10. Smoker

Locations (1)

Clinical Trial Center

Zurich, Switzerland

Outcomes

Primary Outcomes

Aera of flare reaction (cm2), area of primary and secondary hyperalgesia (cm2)

Time frame: 1 year

Data from ClinicalTrials.gov

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