The Clinical Significance of Minimal Change in Reflux Esophagitis Based on the Gastroesophageal Reflux Disease Questionnaire

Inclusion Criteria: * Age ≥ 20 years old patients who consent to revealing their medical information and be able to respond to questionnaires regarding the symptom. * Patients who had shown the reflux esophageal minimal change in the endoscopic finding: the reflux esophagitis Exclusion Criteria: * Patients who had shown the mucosal break or barrett esophagus at gastric mucosal barrier or lower oesophagus in endoscopic findings * Patient with a diagnosis of gastroesophageal reflux disease and who have received medication treatment * Patient who had received H2-receptor antagonists, prostaglandin, PPI, NSAIDs or aspirin, high dose steroid and anticoagulants for at least 5 consecutive days in the 4-week period immediately preceding the diagnostic endoscopy * Patients with a history of operation due to gastrointestinal disease, malignancy, alcoholism, pregnancy (in female), breast feeding (in female) or systemic disease