Association Between Perioperative Platelet Function and Major Adverse Perioperative Events

Hamilton Health Sciences Corporation250 enrolled

Overview

This study will examine the degree of blood thinning (platelet function) in patients coming for non-cardiac surgery on antiplatelet agents using platelet function tests called thromboelastography (TEG) and platelet mapping assay (PMA) and major cardiac complications that occur any time after surgery (perioperative).

Patients who have had stents in their coronary arteries (PCI) have to stay on antiplatelet agents to prevent clotting of their stents. These patients often require non-cardiac surgery (NCS) at some stage after their PCI. The rate of major cardiac complications (MACE)in this population is very high and it is unclear why they are at higher risk than the general population. It is possible their antiplatelet is not adequate, or that surgery causes them to be more clot prone. This is a prospective, multicentre observational study.

Study Type

OBSERVATIONAL

Enrollment

250

Conditions

Surgery

Interventions

Blood drawnPROCEDURE

Blood samples will be taken once in the preoperative clinic and once again at the end of the surgery in the post anesthetic care unit to do the TEG and PMA tests.

Eligibility

Sex: ALLMin age: 30 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients between ages 30-85 years old, receiving post-PCI aspirin and/or clopidogrel therapy * patients undergoing non-ambulatory, NCS * patients will have received a bare metal coronary stent within the last 12 months or a drug eluting stent at any time prior to their NCS * the type of surgery has to be such that there are no contra-indictions to remain on an anti-platelet agent * surgeon must agree to keep the patient on at least one anti-platelet agent during the perioperative period Exclusion Criteria: * clotting abnormalities * drugs affecting platelet function other than aspirin or clopidogrel * moderate renal impairment * liver dysfunction with co-existing thrombocytopenia

Locations (3)

Hamilton Health Sciences

Hamilton, Ontario, Canada

London Health Sciences Centre

London, Ontario, Canada

University Health Network

Toronto, Ontario, Canada

Outcomes

Primary Outcomes

Relationship between platelet function and MACE during the perioperative period

Time frame: 1 month

Secondary Outcomes

Association of MACE with perioperative platelet function as measured by TEG and PMA

Time frame: 1 month

Data from ClinicalTrials.gov

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