Marine n-3 Polyunsaturated Fatty Acids in Pre- and Postmenopausal Women

Aalborg University Hospital92 enrolled

Overview

The study is a randomised placebo controlled double-blinded clinical trial where a group of healthy pre- and postmenopausal women is randomised to the intake of fish oil capsules or placebo oil capsules for 12 weeks. Anthropometric measurements(weight, height,blood pressure) blood samples and adipose tissue biopsies will be taken in order to illustrate the effect of marine n-3 PUFAs (fish oil) on the concentration of circulating female hormones and to investigate what impact menopause might have on the ability to incorporate marine n-3 PUFAs into tissues.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

QUADRUPLE

Enrollment

Conditions

Postmenopause Premenopause

Interventions

marine n-3 polyunsaturated fatty acidsDIETARY_SUPPLEMENT

Four capsules daily containing 2.2 g marine n-3 polyunsaturated fatty acids in total

thistle oilDIETARY_SUPPLEMENT

four capsules a day

marine n-3 polyunsaturated fatty acidsDIETARY_SUPPLEMENT

Four capsules daily, 2.2 g marine n-3 PUFAs in total

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * age 18-70 years old * healthy or well-treated chronic disease Exclusion Criteria: * hormone treatment * foreseen compliance problem * fish oil consumers

Locations (1)

Center for cardiovascular research, Aalborg Hospital

Aalborg, Denmark

Outcomes

Primary Outcomes

Content of marine n-PUFAs as percent of total content of fatty acids in adipose tissue and in platelets before and after intervention

Secondary Outcomes

Measurement of oestrogen concentrations in blood before and after intervention

Data from ClinicalTrials.gov

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