Interaction of Apelin and Angiotensin in the Human Forearm Circulation

University of Edinburgh12 enrolled

Overview

The apelin-APJ system is a relatively new discovery. It has generated interest in part due to it's apparent ability to counteract the renin-angiotensin system, which is frequently overactive in many cardiovascular disease. Apelin has the ability to cause blood vessels to relax, increasing their diameter and hence blood flow down the blood vessel. The researchers wish to investigate the hypothesis that an infusion of apelin will reduce the effects of angiotensin II, which is know to reduce the diameter of blood vessels.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Heart Disease Vasodilation

Interventions

Angiotensin IIDRUG

Infusion of up to 30picmol/ml angiotensin II will be infused and respondent vasoconstriction assessed.

Noradrenaline infusionDRUG

Infusion of up to 480 picomol/ml of noradrenaline will be infused.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 85 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * \> 18 years old * Healthy volunteers Exclusion Criteria: * Lack of informed consent * Age \< 18 years, * Current involvement in other research studies, * Systolic blood pressure \>190 mmHg or \<100 mmHg * Malignant arrhythmias * Renal or hepatic failure * Haemodynamically significant aortic stenosis * Severe or significant co morbidity * Women of childbearing potential. * Any regular medication * Previous history of any cardiovascular disease

Locations (1)

Clincial Research Facility, Royal Infirmary of Edinburgh, 51 Little France Cresc

Edinburgh, United Kingdom

Outcomes

Primary Outcomes

Change in angiotensin II mediated vasoconstriction

Time frame: 12 months

Secondary Outcomes

Changes in relevant neurohumoral hormones in response to apelin infusion

Time frame: 12 months

Data from ClinicalTrials.gov

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