Abraxane and RT for Non-Small Cell Lung Cancer (NSCLC)

Inclusion Criteria: * Histologically confirmed NSCLC. * Clinical or pathologic stage IIIA (T1-3N2M0, T3N1M0) and IIIB (Any T N3M0, T4 Any N M0) diseases according to the American Joint Committee of Cancer criteria. * Patients with malignant pleural effusion will be excluded. * The primary tumor must be radiographically measurable. * Age \> 18. * Karnofsky performance status \> 70 or Zubrod PS 0 or 1. * FEV1 sufficient for patients to tolerate radiation therapy, which is at the discretion of the radiation oncologist, usually \> 800 ml, but may be higher or lower depending on the volume of radiotherapy portal, which is a variable of the tumor extent. * WBC \> 3000; platelet count \> 100,000; absolute neutrophil counts \> 1,500; HGB \> 9.0 g/dl, serum creatinine \< 1.5 mg/dl or creatinine clearance \> 60 ml/min. Laboratory values must be obtained \< 4 weeks prior to registration. * Patients with equivocal enlargement of adrenal gland(s) on CT scan, or a few equivocal regional or distant lesions on any imaging studies need further imaging study (PET, bone scan, or others) or biopsy to rule out distant metastasis. * Patients must have adequate liver functions: AST and ALT \< 2.5 x upper limit of normal, alkaline phosphatase \< 2.5 x upper limit of normal, unless bone metastasis is present in the absence of liver metastasis. Bilirubin \<1.5 mg/dL. * Pre-existing neuropathy must not be worse than grade I. * A signed informed consent. * Normal organ function including EKG findings deemed acceptable for chemotherapy by the medical oncologist. Exclusion Criteria: * Patients with distant metastasis (stage IV disease). * Patients without measurable disease. * Patients with medical contraindication to chemotherapy or radiotherapy. * Patients with myocardial infarction within the preceding 6 months or symptomatic heart disease, including angina, congestive heart failure, uncontrolled arrhythmia. * Patients with bilirubin elevated above institutional upper limit of normal (ULN) must be excluded. * Women who are pregnant or breastfeeding are not eligible. * Other serious illnesses or medical conditions