Post-operative Efficacy and Safety Study

Inclusion Criteria: * Males or females, 18 years of age or older, who have completed outpatient knee arthroscopy * Have an initial pain intensity score of between 30mm and 70mm on a 100mm Visual Analogue Scale(VAS) and a categorical pain rating scale of none, mild, moderate, or severe, * Have been informed of the nature of the study and provided written informed consent Exclusion Criteria: * Have a positive pregnancy test * Have received any of the following medications within 24 hours prior to dosing: COX2 inhibitors, Minor Tranquilizers, Muscle relaxants, Antihistamines * Long-acting oral and parenteral analgesics are prohibited for at least 12 hours prior to receiving study medication. * Have received any of the following medication within 48 hours prior to dosing: Chronic use of analgesics (opioid or non-opioid including aspirin \[\>325 mg/day\], acetaminophen, and NSAIDs) * Have received MAOI drugs within 2 weeks prior to dosing * Not stabilized on the following medications for at least 4 weeks prior to dosing: Tricyclic antidepressant drugs, Serotonin reuptake inhibitors, Amphetamines used for ADHD