Study of the Molecular Genetics of Menstrual Migraine

Inclusion Criteria: All cases and controls must: * Be over 18 years * Caucasian * Provide written, informed consent * Clearly understand and be able to comply with all the trial procedures, as required * Not have taken part in trials of any investigational products within the previous 4 weeks DNA Study: * Cases must have at least a 12-month current or past history of menstrual migraine RNA Study: * Cases must have at least a 12-month current history of menstrual migraine * Cases must have kept at least three months of headache diary data in advance of visit in order to confirm diagnosis * Controls must still be having menstrual periods Exclusion Criteria: DNA Study: * Cases and controls must not have smoked, chewed gum or consumed any food or drink in the 30 minutes prior to sample collection RNA Study: * Cases and controls will not be eligible for participation if they have: * Polycystic ovarian syndrome; * Taken any hormones or drugs in the previous three months that may affect normal hormone activity (e.g., hormonal contraceptives, hormone replacement therapy, dietary supplements such as isoflavones); * Donated or lost a significant amount of blood (\> 550 mL) within the previous 12 weeks * Additionally, controls must not have a personal or family history in any first-degree relative of current or past migraine