Xeloda or UFT (Tegafur-uracil) With Folinic Acid in Advanced or Metastatic Colorectal Cancer

Inclusion Criteria: * Locally advanced or metastatic colo-rectal cancer * Age \> or = 18 years old * PS-WHO \< or = 2 * Polynuclear neutrophil leukocytes \> or = 1500/mm3, platelets \> or = 100000/mm3 * Total bilirubin \< or = 3 ULN, ASAT-ALAT \< or = 2.5 ULN * Effective contraception * Written informed consent signed Exclusion Criteria: * Concomitant radiotherapy * Contraindication to fluoropyrimidines * Treatment with sorivudine and its chemical analogs such as brivudine * Severe hepatic insufficiency * Severe renal insufficiency * Pregnant or lactating woman * Hypersensitivity to capecitabine, 5FU, tegafur or one of its excipients