Predictors of Anticoagulation Control on Warfarin Therapy

University of Pennsylvania687 enrolled

Overview

The goal of this research study is to develop better dosing of anticoagulation medication in both Caucasian and African Americans through analysis of various genetic factors.

This is a prospective cohort study among adult patients requiring warfarin therapy. Patients presenting for anticoagulation will be identified at the start of therapy and followed throughout their course until they reach maintenance dose. We will then develop a dosing equation for warfarin using patient, environmental and genetic factors.

Study Type

OBSERVATIONAL

Enrollment

687

Conditions

Atrial Fibrillation Deep Vein Thrombosis Heart Valve Replacement

Eligibility

Sex: ALLMin age: 21 Years

Medical Language ↔ Plain English

Inclusion Criteria: * All Caucasians and African Americans who are new to warfarin therapy Exclusion Criteria: * Under 21 years of age * Non caucasian * Non african american * Have an abnormal INR before warfarin or heparin therapy * Unable to provide consent

Locations (2)

Hospital of the University of Pennsylvania, Anticoagulation Management Center

Philadelphia, Pennsylvania, United States

Philadelphia Veteran Affairs Medical Center

Philadelphia, Pennsylvania, United States

Data from ClinicalTrials.gov

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