Study of ADAMTS-13 Activity, Von Willebrand Factor and Platelet-Monocyte Aggregation in Coronary Artery Disease

University College Cork11 enrolled

Overview

The purpose of this research is to determine the relationship between proteins and enzymes in the blood and how they work with platelets to form blood clots in patients with coronary artery disease. The investigators hypothesize that the relationship between these factors could potentially be useful in identifying patients at higher risk for heart attacks.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Coronary Artery Disease

Interventions

Blood drawsOTHER

Observational: blood draws only

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Admission to hospital with suspected index event of Non-ST-Elevation Myocardial Infarction (NSTEMI), Unstable Angina (UA) or Stable Angina (SA) * Planned percutaneous coronary intervention during admission Exclusion Criteria: * Recent history (\< 6 months) of an acute coronary syndrome (other than current admission) or stroke * Recent history (\< 6 months) of major surgery, trauma or thromboembolic event * Percutaneous coronary or peripheral intervention or any stent placement performed within the past 6 months * Current evidence of infection

Locations (2)

Cork University Hospital

Cork, Ireland

Beaumont Hospital

Dublin, Ireland

Outcomes

Primary Outcomes

relationships between ADAMTS-13 activity, von Willebrand factor antigen and platelet-monocyte aggregates levels

Assess the relationships between ADAMTS-13 activity, von Willebrand factor antigen and platelet-monocyte aggregates levels in subjects with coronary artery disease prior to and after undergoing PCI in this exploratory study

Time frame: change from baseline to after percutaneous coronary intervention

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.