The purpose of this study is to assess the concentration of besifloxacin compared to gatifloxacin and moxifloxacin in human conjunctival tissue, following a single drop of the drug instilled topically into the study eye. Conjunctival biopsies will be performed at specified time points, followed by the use of loteprednol etabonate/tobramycin ophthalmic suspension four times a day for 5 days.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SCREENING
Masking
DOUBLE
Enrollment
119
Gatifloxacin 0.3% one drop instilled into study eye at visit 2.
Moxifloxacin 0.5% one drop instilled into study eye at visit 2.
Besifloxacin 0.6% one drop instilled into study eye at visit 2.
Bausch & Lomb Incorporated
Rochester, New York, United States
Concentration of besifloxacin, gatifloxacin or moxifloxacin in conjunctival tissue.
Time frame: Biopsies collected at specified time points from 15 minutes to 24 hours
Visual acuity
Time frame: Day -14 through Day 6(+/-1)
Slit Lamp Biomicroscopy
Time frame: Day -14 through Day 6 (+/-)
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