In this study the investigators wish to explore the potential neuroprotective effects of acute oral supplementation of lycopene, a natural anti-oxidant derived from tomatoes, on cerebral vasospasm and autoregulation, and examine whether any improvements translate into a reduction of biochemical markers of vascular injury and inflammation a decrease in the prevalence of secondary strokes following subarachnoid haemorrhage.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
124
Addenbrooke's Hospital
Cambridge, Cambridgeshire, United Kingdom
Incidence of vasospasm
Mean flow velocity in MCA \> 120 cm/min; LR \> 3 (4 if age \< 50 years old)
Time frame: Daily for 21 days
Duration of impaired autoregulation measured with transcranial Doppler
Transient hyperaemic response test; Mx
Time frame: Daily for 21 days
Level of biochemical markers of vascular injury: LDL, oxy-LDL, CRP, circulating endothelial cells, endothelial progenitor cells
Time frame: Days: 0, 3, 6, 12, 14, 21
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