Establishment of Optimal Transfusion Threshold After Major Orthopedic Surgery

Rigshospitalet, Denmark67 enrolled

Overview

The purpose of this study is to determine whether a higher threshold for transfusion with red blood cells improves the postoperative ambulation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Anemia Arthroplasty Replacement Hip

Interventions

Allowed drop in hemoglobin to 4.5-5.5 mmol/LOTHER

Transfusion with red blood cells to hemoglobin between 4.5-5.5 mmol/L (Transfusion threshold of 4.5 mmol/L)

Allowed drop in hemoglobin to level between 5.6-6.5 mmol/LOTHER

Transfusion with red blood cells to between hemoglobin 5.6-6.5 mmol/L (Transfusion threshold of 5.5 mmol/L)

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 18 years or older * Patients undergoing replacement of hip arthroplasty * Be legally competent * Read and understand Danish Exclusion Criteria: * Present malignant disease * Known heart disease with functionality equivalent to NYHA II or CCS II or worse

Locations (2)

Bispebjerg Hospital

Copenhagen, Copenhagen NV, Denmark

Copenhagen University Hospital, Rigshospitalet

Copenhagen, Østerbro, Denmark

Outcomes

Primary Outcomes

Timed Up and Go-test (TUG)in seconds.

Timed Up and Go-test is performed when the patient is able to undertake the test after surgery. This is judged by a physiotherapist. The test measures how long it takes the patient to rise, walk 3 meters, turn around, walk back and sit down again.

Time frame: 30 days

Secondary Outcomes

The postoperative day patients can walk ten meters

Time frame: 30 days

Length of stay at hospital

Time frame: 30 days

The day the patient is able to perform Timed Up and Go-test

Time frame: 30 days

Data from ClinicalTrials.gov

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