A Study of MF101 in Postmenopausal Women

Inclusion Criteria (limited): * Confirmed postmenopausal women aged 40-65 * Provide written informed consent Exclusion Criteria (limited): * History of malignancy, with the exception of certain types of skin cancer or cervical cancer * Known carrier of BRCA1 or BRCA2 * Abnormal mammogram or breast examination suggestive of cancer within 9 months of screening * Endometrial hyperplasia, polyps or abnormal uterine masses (with the exception of fibroids) * Clinical evidence of active ischemic heart disease, history of cardiovascular disease, uncontrolled hypertension, or a history of transient ischemic attacks or cerebrovascular accidents * History of deep vein thrombosis, pulmonary embolism, severe chronic diarrhea, chronic constipation, uncontrolled inflammatory bowel syndrome or disease (IBS or IBD), or unexplained weight loss * Active liver disease or gall bladder disease * History of chronic hepatitis B, hepatitis C, hepatitis within 3 months, or HIV infection * Use of prescription medications or herbal/dietary supplements for the treatment of hot flushes or those with known estrogenic/progestogenic activity within required wash-out timeframes * Use of selective receptor modulators (SERMs), aromatase inhibitors, gonadotropin-releasing hormone agonists, selective serotonin reuptake inhibitors (SSRIs), selective norepinephrine reuptake inhibitors (SNRIs), gabapentin or clonidine within required wash-out timeframes * Chronic use of morphine or other opiates