Emdogain and Straumann Bone Ceramic in Infrabony Defects

Inclusion Criteria: * Males and females must be at least 18 years and not more than 75 years of age * The patient will have to be able to understand and sign the informed consent prior to starting the study. * The patient also will have to have the ability and the willingness to comply with all study requirements. * The patients will be in good general health without any systemic diseases. * The teeth included in the study will be mandibular molars, maxillary and mandibular premolars, and canines. * The patients will have to have at least one defect with pocket depth ≥ 5 mm. * Intra-bony defects will have to have 1 or 2-wall morphology (at least 2/3 of the defect). * Depth of the intrabony component of at least 3 mm * The selected sites will have to have vertical intra-bony component ≥ 3 mm and an angle ≥ 30 degrees as assessed from standardized intra-oral radiographs. * Oral hygiene parameters: Plaque Index (PI) ≤ 20 % and bleeding on probing (BoP) ≤ 20% Exclusion Criteria: * Heavy smokers: more than 20 cigarettes per day * Mucosal diseases such as erosive lichen planus * History of local radiation therapy * Presence of oral lesions (such as ulceration, malignancy) * Teeth with untreated endodontic or cardiologic problems * Physical handicap that will interfere with patient's ability to exercise good oral hygiene on a regular basis. * Patients presenting antibiotic treatment within the 3 months preceding the surgical procedure. * Patients using anti-inflammatory drugs on a regular basis. * Intra-bony defects with a 3-wall morphology. * Intra-bony defects with furcation involvement. * Incisors and maxillary molars, will be excluded. * Alcoholism or chronically drug abuse causing systemic compromize * Medical conditions requiring prolonged use of steroids * Current pregnancy at the time of recruitment and/or breastfeeding women. * Conditions or circumstances, in the opinion of the investigator, which could represent a general contra-indication for surgical procedure or would prevent completion of study participation or interfere with analysis of study results, such as history of non-compliance, or unreliability.