BAY81-8781, I.V. Aspirin in the Indication of Acute Coronary Syndrome (ACS)

Inclusion Criteria: * Angina pectoris lasting for more than 20 minutes within the last 24 hours before study drug treatment (or equivalent acute symptoms such as increasing dyspnea, diaphoresis, nausea, abdominal/epigastric pain, syncope etc.) * ECG change suggestive for ischemia: * ST elevation or T-wave change or ST depression, new or presumed left bundle-branch block (LBBB) * Elevated troponin T level \> 0.01 ng/ml, levels according to local laboratory reference values * Risk factors for ACS such as known coronary artery disease (CAD), diabetes mellitus, impaired renal function, peripheral artery or cerebrovascular disease, current smoking. Exclusion Criteria: * Treatment with acetylsalicylic acid (ASA) within 48 hours prior to study drug treatment * Treatment with glycoprotein IIa/IIIb inhibitors within 48 hours prior to study drug treatment and before the 20 minutes blood samples for thromboxane, prostacycline and platelet aggregation measurement have been taken * Thrombolytic therapy within 24 hours before study drug treatment * Obligation for tracheal intubation and mechanical ventilation * Contraindications to ASA treatment * Known haemorrhagic diathesis * Evidence of an active gastrointestinal or urogenital bleeding * Stroke within 3 months prior to study drug treatment * Major surgery including coronary artery bypass graft (CABG) within 6 weeks prior to study drug treatment * Known severe hepatic or renal insufficiency * Pregnant or breast-feeding women