Study of Intravenous GMI-1070 in Adults With Sickle Cell Disease

Inclusion Criteria: * Age 18 to 45 years * Established diagnosis of SCD-SS or SCD-SB0-thal * At medical baseline, with no evidence of worsening of disease over the last 3 months * Available and agree to return for follow-up visits for the full duration of the study * Able to cooperate with study procedures * Documented and observed written informed consent Exclusion Criteria: * Vaso-occlusive crisis * Recent major surgery, hospitalization, infection, significant bleeding, cerebrovascular accident or seizure, or transfusion * Currently receiving, or has received within the previous 4 weeks, any other investigational agent * Pregnant or lactating female; or female of childbearing age unable or unwilling to comply with birth control or abstinence during the course of the study