Does APOE-e4 Predict Delirium and Cognitive Dysfunction After Surgery?

Ottawa Hospital Research Institute100 enrolled

Overview

Patients with the APOE-ε4 genotype are at increased risk of both vascular dementia and peripheral vascular disease. Patients undergoing major vascular surgery are at particularly high risk of delirium and other, more subtle, changes in cognitive function following surgery. The hypothesis of this trial is that the APOE-ε4 genotype is associated with both delirium and postoperative cognitive dysfunction (POCD).

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Delirium Postoperative Cognitive Dysfunction

Eligibility

Sex: ALLMin age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age 60 or greater * Open repair of the abdominal aorta Exclusion Criteria: * refusal; * planned endovascular repair; * emergency surgery; * previous diagnosis of dementia, Parkinson's disease, or psychiatric illness; * active alcohol or substance abuse; and * physical inability to complete neuropsychometric testing.

Locations (1)

The Ottawa Hospital - Civic Campus

Ottawa, Ontario, Canada

Outcomes

Primary Outcomes

Delirium as assessed by the Confusion Assessment Method

Time frame: 7 days postoperatively

Secondary Outcomes

POCD as assessed by a battery of 9 neuropsychometric tests

Time frame: 7 days postoperatively

POCD as assessed by a battery of 9 neuropsychometric tests

Time frame: 3 months postoperatively

Data from ClinicalTrials.gov

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