Non Invasive Mechanical Ventilation in Acute Cardiogenic Pulmonary Edema

Assiut University129 enrolled

Overview

Cardiogenic pulmonary edema (CPE) is a common medical emergency and noninvasive ventilation (NIV) in addition to conventional medical treatment might be beneficial for patients with CPE.

To evaluate the effect of adding continuous positive airway pressure (CPAP) or bilevel positive airway pressure (BiPAP) to standard medical therapy (ST) on intensive care unit (ICU) stay, hospital stay, mortality, need for endotracheal intubation, partial arterial O2 tension (PaO2), intrapulmonary shunt, alveolar-arterial (A-a) oxygen gradient, and cardiac output in patients admitted to the respiratory intensive care unit (ICU) or cardiac care unit (CCU) with acute CPE with gas exchange abnormalities and to evaluate the impact of heart failure type on the outcome of different therapeutic schedules.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

129

Conditions

Acute Cardiogenic Pulmonary Edema

Interventions

standard therapy (ST)OTHER

standard medical therapy

CPAPDEVICE

Non-invasive mechanical ventilation (CPAP)

BIPAPDEVICE

Non-invasive mechanical ventilation (BIPAP)

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. CPE confirmed radiologically and/or clinically 2. Severe acute respiratory failure (partial arterial oxygen (PaO2)/Fraction of inspired oxygen (FIO2) less than 250) 3. Dyspnea of sudden onset with respiratory 4. Systolic blood pressure \< 180 mmHg Exclusion Criteria: 1. Immediate need for endotracheal intubation: * Severe sensorial impairment * Shock * Ventricular arrhythmias, * Life-threatening hypoxia (SpO2 \[oxygen saturation as indicated by pulse oximetry\] less than 80% with oxygen) * Acute myocardial infarction necessitating thrombolysis * Cardiac or respiratory arrest 2. Severe chronic renal failure 3. Pneumothorax. 4. Contraindication of non invasive ventilation (NIV)

Locations (1)

Assiut University Hospital

Asyut, Egypt

Outcomes

Primary Outcomes

Number of Patients Who Were Intubated

Number of patients who were subjected to endotracheal intubation and invasive mechanical ventilation

Time frame: During ICU Stay

Secondary Outcomes

Arterial Blood Gases, Respiratory Rate, Blood Pressure, Cardiac Output ,Intrapulmonary Shunt, A-a Oxygen Gradient, Heart Rate, and Dyspnea Duration of Hospital and ICU Stay and Mortality

Time frame: Hospital stay

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.