Vascular Effects of Hesperidin in Metabolic Syndrome

University of Rome Tor Vergata30 enrolled

Overview

It has been suggested that cardiovascular risk factors either independently or in cluster (metabolic syndrome) increase the risk of both type 2 diabetes (DM2) and cardiovascular diseases (CVD). Consumption of citrus fruits is linked to reduced cardiovascular morbidity and mortality. Hesperidin is a flavanone abundant in citrus fruit with putative vasodilator actions in vitro. While molecular mechanisms of vascular actions of hesperidin begin to be explored, no data on in vivo vascular effect of this flavanone has been ever acquired.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Endothelial Dysfunction Metabolic Syndrome

Interventions

HesperidinDRUG

Administration of oral Hesperidin, 500 mg/daily

PlaceboDRUG

Administration of oral Placebo, 500 mg/daily

Eligibility

Sex: ALLMin age: 20 YearsMax age: 55 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Metabolic Syndrome (ATPIII criteria) * BMI \<35 * Age 20-55 Exclusion Criteria: * History of cancer. * History of cardiovascular diseases. * Any other acute or chronic illness which requires administration of steroids or other drugs able to interfere with glucose or lipid metabolism.

Locations (1)

University of Rome Tor Vergata

Rome, Rome, Italy

RECRUITING

Outcomes

Primary Outcomes

Safety of oral supplementation of hesperidin

Time frame: 3 weeks

Secondary Outcomes

Endothelial function assessed by FMD %. Inflammatory status assessed by biochemical markers.

Time frame: 3 weeks

Data from ClinicalTrials.gov

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