Behavioral Treatment for Cocaine Dependent Women

Yale University145 enrolled

Overview

To compare the efficacy of Community Reinforcement Approach (CRA) and 12-Step Facilitation (TSF) counseling and of voucher based reward therapy (VBRT) and a yoked, non-contingent voucher control (VC) for the treatment of cocaine dependent pregnant women or women with young children.

Subjects were randomly assigned to 1 of 4 treatment groups (CRA+VBRT, CRA+VC, TSF+VBRT, TSF+VC). VBRT voucher value increased for each successive cocaine-free urine sample obtained twice weekly during the 1st 12 weeks and was faded from the final earned value to $5 during the last 12 weeks. All subjects earned vouchers for attendance at scheduled twice weekly counseling sessions. Manual-guided CRA and TSF were provided by experienced clinicians.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

145

Conditions

Cocaine Dependence

Interventions

Behavioral therapyBEHAVIORAL

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Pregnant women meeting DSM IV criteria for cocaine dependence * Women meeting DSM IV criteria for cocaine dependence with custody of a young child Exclusion Criteria: * Opioid dependence * Psychosis * Severe depression * Current treatment with any anti-depressant or anti-psychotic medication * Medical instability * Inability to understand or read English

Locations (2)

The APT Foundation, Inc. MRU

New Haven, Connecticut, United States

Yale University School of Medicine

New Haven, Connecticut, United States

Outcomes

Primary Outcomes

Cocaine abstinence

Time frame: 24 weeks

Secondary Outcomes

Reduced HIV risk behavior

Time frame: 24 weeks

Data from ClinicalTrials.gov

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