Berlin Magnetic Seizure Therapy Depression Trial 01

Inclusion Criteria: * Patient is diagnosed with a severe major depressive episode * Patient is in a chronic current MDE and/or has had a history of recurrent MDEs * Patient has not had an acceptable clinical response due to failure with at least 2 antidepressant treatments during the current episode * Patient has a score \> 20 on the HAMD24 * Patient is stable on current psychotropic medication for at least 4 weeks * Patient is \> 25 and \< 80 years Exclusion Criteria: * Atypical Depression or psychotic depression (according to DSM IV) * Other relevant psychiatric axis I or axis II diseases * Relevant neurological diseases * Relevant cardiac or pulmonary diseases with enhances anesthesiological risk (ASA Score \> 3) * Patient is currently enrolled in another investigational study not associated with the current study * Patient has a history of, or evidence of, significant brain malformation or significant head injury