Concentrations of Salmeterol in Blood and Urine

Bispebjerg Hospital30 enrolled

Overview

The purpose of the study is to assess the blood and urine concentrations of inhaled salmeterol.

The purpose of the study is to assess the serum and urine concentrations of salmeterol after inhalation of 100 microgram salmeterol in one dose. Furthermore, to evaluate any difference in three groups: 10 healthy men, 10 male asthmatic subjects and 10 male elite athletes with asthma.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Masking

NONE

Enrollment

Conditions

Asthma

Interventions

inhaled salmeterolDRUG

Inhalation of 100 micrograms salmeterol in one dose.

Eligibility

Sex: MALEMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Physician-diagnosed asthma with positive reversibility or challenge test. * Informed consent. * Age between 18-45 years. * Sex: male. * Asthma classified as mild to moderate according to GINA guidelines. * Used beta-2-agonist in minimum 12 months. Exclusion Criteria: * Smokers or ex-smokers with a smoking history of 10 pack years or more. * Respiratory tract infections within the last 2 weeks prior to study day. * Subjects with other chronic diseases than asthma and/or allergy. * Allergy towards the study medicine. * Use of beta-2-agonist 10 days prior to study day.

Locations (1)

Bispebjerg Hospital, Respiratory Research Unit

København NV, Denmark

Outcomes

Primary Outcomes

Serum and urine concentrations of salmeterol

Time frame: baseline, 4, 8, and 12 hours after medicine administration

Central Contacts

Jimmi Elers, MD

CONTACT

+45 35313208 jele0004@bbh.regionh.dk

Data from ClinicalTrials.gov

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