Positron Emission Tomography (PET)-Scan in the Evaluation of High Tumor Burden Follicular Lymphoma

Inclusion Criteria: * Patients with malignant non-Hodgkin follicular lymphoma (histologic grade 1 to 3 in the WHO classification), histologically confirmed, * Patients who have not previously been treated for this disease, * Introducing one of the criteria for high tumor burden, * Patients aged over 18 and under 80 years, * Patients whose ECOG condition is ≤ 2, * Patients whose haematological functions are adequate within 28 days preceding the treatment (Hemoglobin ≥8,0g/dl; Neutrophils ≥1,5e-9/L, Platelets ≥100e-9/L), * Patient had the PET examination less than a month before the start of chemotherapy. Exclusion Criteria: * Patients with lymphoma who have already transformed or been treated for this disease, * Patients whose lymphoma is stage 3b, * Patients with impaired central nervous system, * Patients regularly taking corticosteroids during the 4 weeks preceding the treatment (unless the dose administered is equivalent to ≤20 mg/day prednisone). * Patients who have undergone major surgery during the 28 days preceding the inclusion, * Patients with low kidney and/or liver function, * Patients with HIV + or had an infection with HBV or HCV less than 4 weeks. Patients with hepatitis B serology is positive unless the sign is related to vaccination, * Patients whose life expectancy ≤ 6 months, * Patients sensitive or allergic to murine products, * Patients who participated in another clinical trial during the 30 days preceding the recording, * Patients with other medical problems or psychological succeptibles interfere with the study, * Patients under adult supervision.